Unit Price:
৳ 4.00
(30's pack: ৳ 120.00)
Indications
Ulnid is indicated for Amoebiasis (Intestinal and hepatic), Giardiasis, Trichomoniasis, Bacterial vaginosis, Treatment of susceptible anaerobic infections
Pharmacology
Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Dosage & Administration
Amoebiasis:
Bacterial vaginosis: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.
- Adults: 500 mg twice a day for 5 days.
- Children: 10-25 mg per kg body weight in two divided doses.
- Adults: 1.5 gm once a day for 3 days.
- Children: 40 mg per kg body weight, once a day for 3 days.
- Adults: 1.5 gm once daily for 1-2 days.
- Children: 40 mg per kg body weight for 2 days.
Bacterial vaginosis: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Interaction
Like other imidazoles, Ulnid has a mild potential to cause disulfiramlike reactions. Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished hepatic metabolism. Ulnid has been reported to decrease the clearance of 5-fluorouracil.
Contraindications
Previous hypersensitivity to Ornidazole and to other nitroimidazoles. Ornidazole is contraindicated in central nervous system disorders, particularly in epilepsy or in peripheral neuropathy.
Side Effects
Side effects of Ulnid have been mainly limited to the gastrointestinal tract (nausea, vomiting, epigastric pain) and central nervous system (dizziness, headache, lassitude). Unlike other nitroimidazoles, Ulnid does not interact with alcohol, although this requires further study.
Leukopenia has been described occasionally during therapy. Adverse central nervous system (CNS) effects of Ulnid have mainly included headache, dizziness, lassitude or somnolence, fatigue and weakness. Adverse CNS effects of Ulnid may be less than that happens with metronidazole. Seizures have not been reported with Ulnid in studies available to date.
Leukopenia has been described occasionally during therapy. Adverse central nervous system (CNS) effects of Ulnid have mainly included headache, dizziness, lassitude or somnolence, fatigue and weakness. Adverse CNS effects of Ulnid may be less than that happens with metronidazole. Seizures have not been reported with Ulnid in studies available to date.
Pregnancy & Lactation
Adequate clinical trials have not been conducted. Ornidazole should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate.
Precautions & Warnings
In patient with ataxia, vertigo, and mental confusion, Ulnid should be prescribed with caution. During prolonged treatment with Ulnid, blood dyscrasia namely mild leukopenia have been reported rarely. In case leukopenia occurs, the decision to discontinue the therapy should depend upon the gravity of infection.
Use in Special Populations
Renal Impairment Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic Impairment Severe: Double the interval between doses.
Hepatic Impairment Severe: Double the interval between doses.
Therapeutic Class
Amoebicides, Anti-diarrhoeal Antiprotozoal
Storage Conditions
Store at room temperature and protect from light and moisture.