Megagard Powder for Solution

Tiamulin Hydrogen Fumarate is a antibiotic of pleuromutilin group. It is a prokaryotic ribosome inhibitor that acts by blocking the initiation of polypeptide chain formation, thus preventing the synthesis of key enzymes and other proteins.

Pharmacokinetics:

• More than 90% absorption at recommended dose.
• Maximum therapeutic concentration within 02 hours after administration.
• 99% tiamulin excreted from blood within 48 hours.
• No side effect, even in case of 03 times excess dose.
• Can be administered with a number of coccidiostats.
• Shows synergistic effect with tetracyclines.

Treatment:

• In water: 25-30 mg/ kg B.W or 1 g/2 L water for 3-5 days
• In feed: 30-40 gm/100 kg feed for 5-7 days

Prevention:

• In water: 1 gm/4 L water for 1-7 days
• In feed: 20 gm/100 kg feed for 3-5 days

Compatible anticoccidials: Lasalocid, Nicarbazin, Semduramicin, Decoquinate, Diclazuril, Amprolium, Halofuginone, Clopidol, Robenidine, Coccidiosis vaccines etc.

Low resistance: Megagard develops resistance very slowly than other antibiotics like Tylosin, Oxytetracycline, Lincomycin & Enrofloxacin.

Negligible cross-resistance: Megagard is an antibiotic of the pleuromutilin family and is not related to other antibiotics, such as the macrolides (tylosin, kitasamycin, erythromycin, josamycin and spiramycin), or the tetracyclines and there is no cross-resistance between the families. Due to its lack of cross-resistance Megagard has been shown to be active against tylosin-resistant strains.

Well tolerated: Toxicity studies have shown Megagard is well tolerated in chickens. The LD5 (where 5% mortality occurs) for chickens is 1090 mg/kg body weight (44 times preventive dose). It is well distributed throughout body tissues and is metabolized and excreted primarily via the liver and kidneys.

Do not use in birds hypersensitive to the active ingredient.

Megagard is suitable for use in laying and breeding birds as it has been shown to have no adverse effects on egg production, fertility and hatchability in chickens.

Birds should not receive feed containing Narasin & Salinomycin during or for at least seven days before or after treatment with Megagard Powder. Severe growth depression or death may result. Concomitant use of tiamulin and the ionophore anticoccidial Maduramycin may lead to a mild to moderate growth depression in chickens. The situation is transient and recovery normally occurs within 3-5 days following withdrawal of THF. 

Withdrawal period: For meat: 03 (three) days. For egg: Nil (Zero)

Protect from light. Store in a cool & dry place. Keep out of reach of children.