Tolicox Oral Solution

Toltrazuril liquid acts both on the schizogony and the gametogony stages of the parasites. Giving treatment by Toltrazuril liquid after the coccidia infection the light and electron microscopic studies showed that all intracellular development stages of Eimeria are damaged. The changes occur only in the parasites and do not affect the tissue cells of the host animals. These findings suggest that toltrazuril interferes with the division of the nucleus and with the activity of the mitochondria, which are responsible for the respiratory metabolism of the parasites. In all intracellular development stages a severe vacuolization due to inflation of the endoplasmatic reticulum occurs. In the macrogametes it damages the so-called wall-forming bodies II. Toltrazuril liquid thus has coccidicidal rather than coccidiostatic action.

Oral administration only.
Poultry:

• Prevention: 1 ml/L drinking water for three medications on 9-10, 16-17 & 23-24 days of life.
• Treatment: 1 ml/L drinking water for 48 hours continuous administration, or 3 ml/L of drinking water for 8 hours per day for 2 consecutive days. Or, 7 mg/kg per day for 2 consecutive days. Medicated drinking water should be used within 24 hours.

Calves, Sheep, Goats & Pigs: 0.8 ml/kg bodyweight for 2 consecutive days. If necessary repeat after 5 days. Or, as directed by the Registered Veterinary Physician.

Tolicox liquid is compatible with other poultry feed additives & no hazardous reactions were reported.

Should not be administered in flocks with impaired hepatic and renal function. Should not be used in animals hypersensitive to active ingredient.

Common side effects: Tolicox is well tolerated in recommended dose.

Rare side effects: At high doses in laying hens egg-drop, and in broilers growth inhibition and polyneuritis may occur.

Withdrawal period:

• Poultry: Meat- 8 days, Egg- Should not be used in laying birds producing eggs for human consumption.
• Ruminants and Pigs: Meat- 77 days, Milk- Should not be used in lactating animals producing milk for human consumption.

3-5 times overdose is readily tolerated without any symptoms. If the recommended dose is exceeded beyond 3-5 times, there is a decrease in water intake.

Store in a cool & dry place. Protect from sunlight & moisture. Keep out of reach of children.