Bolus Tablet

Amodav-DS Vet Bolus Tablet

Veterinary
800 mg+200 mg
Unit Price: ৳ 20.00 (18's pack: ৳ 360.00)
Also available as:

Indications

This is indicated for short-term treatment of bacterial infections at the following sites:
  • URTI (including ENT); e.g., tonsillitis, sinusitis, otitis media.
  • LRTI; e.g., acute and chronic bronchitis, lobar and bronchopneumonia.
  • Genito-urinary tract infections; e.g., cystitis, urethritis, pyelonephritis. SSTI.
  • Bone and joint infections; e.g., osteomyelitis.
  • Other infections; e.g., septic abortion, puerperal sepsis, intra-abdominal sepsis, etc.

Pharmacology

Pharmacodynamic properties: Co-amoxiclav is an antibacterial combination consisting of the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram-positive & Gram-negative microorganisms but it is susceptible to degradation by (3-lactamases and therefore the spectrum of activity does not include microorganisms, which produce these enzymes. Clavulanic acid possesses the ability to inactivate a wide range of beta-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. Thus Clavulanic acid in this preparation protects Amoxicillin from degradation by (3-lactamase enzymes and effectively extends the antibiotic spectrum to embrace a wide range of microorganisms.

Pharmacokinetic properties: The pharmacokinetics of the two components of Co-amoxiclav is closely matched. Peak serum levels of both occur about one hour after oral administration. Absorption of Co-amoxiclav is optimized at the start of a meal. Both clavulanate and Amoxicillin have low levels of serum binding; about 70% remains free in the serum. Doubling the dosage of Co-amoxiclav approximately doubles the serum levels achieved.

Dosage & Administration

Dose of Tablets:

Adults and children over 12 years: The usual adult dose is 625 mg Tablet every 12 hours or one 375 mg tablet every 8 hours.

Dose of Powder for Suspensions

Powder for Suspension:
  • 1–6 years: 5 ml 3 times daily or 0.25 ml/kg 3 times daily
  • 6–12 years: 10 ml 3 times daily
Dose of Injections:

Adults: Usually 1.2 g every 8 hours, increased in more severe infections to 1.2 g every 6 hours.
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Interaction

Prolongation of bleeding time and prothrombin time has been reported in some patients receiving Amodav-DS Vet.

Contraindications

History of Penicillin hypersensitivity.

Side Effects

Urticarial and erythematous rashes sometimes occur. In common with other beta-lactam antibiotics angioedema and anaphylaxis have been reported.

Pregnancy & Lactation

Use in pregnancy is not recommended unless considered essential by the physician. During lactation, trace quantities of Amoxicillin can be detected in breast milk.

Precautions & Warnings

This should be used with care in patients on anti-coagulation therapy or with severe hepatic dysfunction.

Storage Conditions

Store below 25°C in a cool & dry place. Protect from light. Keep out of reach of children.