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Indications

Adiron is indicated for the treatment of iron deficiency in adults.

Pharmacology

Ferric Maltol delivers iron for uptake across the intestinal wall and transfer to transferrin and ferritin. It has been shown to increase serum iron parameters, including ferritin and transferrin saturation (TSAT)

Dosage & Administration

Ferric Maltol capsule should be taken in oral route, preferably on an empty stomach, at least 1 hour before or 2 hours after meals. Do not open, break or chew Ferric Maltol capsule. The recommended dosage of Ferric Maltol is 30 mg twice daily. Treatment duration will depend on the severity of iron deficiency but generally at least 12 weeks of treatment is required. The treatment should be continued as long as necessary until ferritin levels are within the normal range.

Use in children and adolescents: Safety and effectiveness of ferric maltol have not been established in pediatric patients.
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Interaction

Drug interaction with medication: Concomitant use of iron products with dimercaprol may increase the risk of nephrotoxicity. Avoid concomitant use of Adiron with dimercaprol. Concomitant use of Adiron may decrease the bioavailability of some drugs, including mycophenolate, ethynyl estradiol, ciprofloxacin and doxycycline. For oral drugs where reductions in bioavailability may cause clinically significant effects on its safety or efficacy, separate the administration of Adiron by at least 4 hours.

Drug interaction with food and others: Food has been shown to decrease the bioavailability of iron after administration of Adiron.

Contraindications

Ferric maltol is contraindicated in patients with known hypersensitivity to ferric maltol or any other components of this product. It is also contraindicated in patients with a history of hemochromatosis and other iron overload syndromes and in patients receiving repeated blood transfusions.

Side Effects

The most common side effects are flatulence, diarrhea, constipation, feces discolored, abdominal pain, nausea and vomiting.

Pregnancy & Lactation

Ferric maltol is not absorbed systemically as an intact complex following oral administration and maternal use is not expected to result in fetal exposure to the drug. There are no data on the presence of ferric maltol in human milk, the effects on the breastfed child or the effects on milk production. Ferric maltol is not absorbed systemically as an intact complex by the mother following oral administration and breastfeeding is not expected to result in exposure of the child to ferric maltol.

Precautions & Warnings

Avoid use of Adiron in patients with an active inflammatory bowel disease (IBD) flare, as there is potential risk of increased inflammation in the gastrointestinal tract. Do not administer to patients with evidence of iron overload or patients receiving intravenous iron. Assess iron parameters prior to initiating Adiron and monitor iron parameters while on therapy. Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6 years of age. In case of accidental overdose, patient should be treated immediately.

Overdose Effects

No data is available regarding overdose of Adiron in patients. Early signs and symptoms of iron overdose may include nausea, vomiting, abdominal pain and diarrhea. In more serious cases there may be evidence of hypoperfusion, metabolic acidosis and systemic toxicity. Dosages of Adiron in excess of iron needs may lead to accumulation of iron in storage sites leading to hemosiderosis.

Therapeutic Class

Oral Iron preparations

Storage Conditions

Store in a cool (below 25°C) and dry place protected from light. Keep away from the reach of children.
Pack Images: Adiron 30 mg Capsule