Bonigen Tablet

Bonigen is indicated in-

• Superior support for aging joints.
• Next-generation, multi-nutrient formula based on latest research.
• Boswellia inhibits 5-LOX enzyme.
• Undenatured Type II collagen standardized chicken cartilage extract supports joint comfort and ease of motion.

Each tablet contains-

• Undenatured Type II collagen 20 mg
• Glucosamine sulfate 750 mg
• Boswellia serrata 50 mg
• Boron (Calcium fructoborate) 0.75 mg

Undenatured Type II collagen: Undenatured Type II collagen is a nutritional supplement derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity. Undenatured Type II collagen has unique mechanism of action. Undenatured Type II collagen molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes o f Undenatured Type II collagen interact with Peyer’s patches (lymphoid tissue) of small intestine and it transforms T-cells into T regulatory cells. T regulatory cells then migrate to joint area and secrete anti-inflammatory mediators (cytokines), including the transforming growth factor-beta (TGF-beta) and interleukin 10 (IL-10). Thus it reduces joint inflammation and promotes cartilage repair. According to ORSI (osteoarthritis research society international), oral administration of Undenatured Type II collagen diminished deterioration of articular cartilage of osteoarthritis (OA).

Glucosamine sulfate: Glucosamine sulfate is a natural supplement. It is a sugar protein that helps to build cartilage. Glucosamine, a normal constituent of glycosaminoglycans in cartilage matrix and synovial fluid, could have various pharmacological actions in articular cartilage and joint tissues. In randomized, placebo-controlled clinical trial, long-term administration of Glucosamine sulphate can prevent joint structure changes in patients with osteoarthritis of the knee with a significant improvement in symptoms.

Boswellia serrata: This plant extract promotes joint health by inhibiting inflammatory factors such as the 5-lipoxygenase (5-LOX) enzyme and leukotriene B4, which affect aging joints. Extract of Boswellia serrata have been clinically studied for osteoarthritis, joint function & joint pain. Boswellia may also help reduce cartilage damage in arthritis. In a placebo-controlled clinical study, Boswellia extract improves signs of joint discomfort in just 8 weeks. Boswellia serrata as a promising alternative to NSAIDs.

Boron (calcium fructoborate): It is a patented complex of calcium, fructose & boron found naturally in fresh and dried fruits, vegetables and herbs. Calcium fructoborate significantly reduces the C-reactive protein in humans. This unique plant-mineral complex is contribute to bone health by controlling the inflammation associated with loss of bone mineral density.

Adult dose: 1 tablet orally twice daily after meal. Or as directed by the physician.

Use in children & adolescents: Safety and effectiveness in children patients below 12 years of age have not been established.

There have been no reports of significant drug Interactions of Undenatured Type II collagen, Boswellia serrata, Glucosamine sulfate, Calcium fructoborate. But in case of Glucosamine sulfate & Boswellia serrata there are a chance of drug interaction with blood thinner medications (e,g warfarin, heparin).

It is known that the following groups of patients should only take the supplements under close medical supervision or should avoid them altogether. Diabetic patients should only use Glucosamine sulfate supplements under close medical supervision, as some studies suggest that Glucosamine sulfate may increase insulin resistance. Patients who are allergic to shellfish should consult their physician before taking Glucosamine sulfate supplements. However, an allergy to shellfish does not usually pose a limitation for taking glucosamine sulfate, as Glucosamine sulfate is extracted from chitin, a carbohydrate, whereas shellfish alergies are most often caused by a protein. Children, as well as women who are pregnant and/or nursing, or who could become pregnant. There is currently not enough research available to determine whether or not taking glucosamine and chondroitin sulfate supplements has negative effects on young children or fetuses. Patients who have any adverse reactions or unusual side effects to glucosamine supplements should discontinue use immediately and consult their physician.

Glucosamine sulfate seems to be safe for most people. It can cause some mild side effects including nausea, heartburn, diarrhea, and constipation. Uncommon side effects are drowsiness, skin reactions, and headache. Some glucosamine products do not contain the labeled amount of glucosamine or contain excessive amounts of Manganese.

Not recommended duration pregnancy and lactation.

In the presence of Glucosamine, diabetics patients are advised to monitor blood glucose labels regularly. No special studies were confirmed in patients with renal and /or hepatic insufficiency. However administration to these patients with severe renal or hepatic insufficiency should be under appropriate medical supervision.

The signs and symptoms of overdose include nausea, vomiting, diarrhoea, constipation and abdominal discomfort.

Specific mineral & vitamin combined preparations

Store below 30° C temperature & in dry place, protected from light. Keep out of the reach of children.