Sodium Picosulfate
Indications
Sodium Picosulfate is indicated in the following conditions-
- Constipation of any etiology
- Relief from prolonged & recurrent constipation
- Bowel clearance before surgery, childbirth or radiological investigations.
Pharmacology
Sodium Picosulfate is a triarylmethane group derivative stimulant laxative. After oral administration it is activated by the colonic bacteria and acts locally in the colon. The active form then stimulates the nerve endings of the intestinal wall and results in colonic peristalsis with promotion of accumulation of water and electrolytes in the colonic lumen. This results in stimulation of defecation, reduction of transit time and softening of the stool. Stimulation of the rectum causes increased motility and a feeling of rectal fullness. The rectal effect may help to restore the "call to stool".
Dosage & Administration
For oral administration. The following dosages are recommended to be taken at night to produce evacuation the following morning. It is recommended to start with the lowest dose. The dose may be adjusted up to the maximum recommended dose to produce regular stools. The maximum recommended daily dose should not be exceeded:
10 mg tablet dose:
10 mg tablet dose:
- Adults and children over 10 years of age: 5-10 mg per day.
- Children aged 4-10 years: 2.5-5 mg per day.
- Adults and children over 10 years of age: 5-10 ml or one to two teaspoonful per day.
- Children aged 4-10 years: 2.5-5 ml or half to one teaspoonful per day.
- Children from One month to 4 years of age: 0.25 ml/kg body weight per day.
- Adults and children over 10 years of age: 0.67-1.33 ml per day.
- Children aged 4-10 years: 0.33-0.67 ml per day.
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Interaction
The concomitant use of diuretics or adreno-corticosteroids may increase the risk of electrolyte imbalance if excessive doses are taken. Concurrent administration of antibiotics may reduce the laxative action of this product.
Contraindications
Ileus or intestinal obstruction, severe painful and/or feverish acute abdominal conditions (e.g. appendicitis) potentially associated with nausea and vomiting, acute inflammatory bowel diseases, severe dehydration, known hypersensitivity to Sodium Picosulfate or any other component of the product.
Side Effects
Hypersensitivity, dizziness, syncope, vasovagal response, gastrointestinal disorders, diarrhea, abdominal pain and abdominal cramps, nausea, vomiting.
Pregnancy & Lactation
There are no reports of undesirable or damaging effects during pregnancy or to the foetus attributable to the use of this product. Use of the drug should be avoided during the first trimester. Clinical data show that neither the active moiety of sodium Picosulfate (BHPM or bis-(p hydroxyphenyl)-pyridyl-2-methane) nor its glucuronides are excreted into the milk of healthy lactating females.
Precautions & Warnings
Prolonged excessive use may lead to fluid and electrolyte imbalance and hypokalemia. Harmful for those suffering from alcoholism. To be taken into account in pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease or epilepsy.
Overdose Effects
Laxatives when taken in chronic overdosage may cause chronic diarrhea, abdominal pain, hypokalemia, secondary hyperaldosteronism, and renal calculi. Renal tubular damage, metabolic alkalosis, and muscle weakness secondary to hypokalemia have also been described in association with chronic laxative abuse.
Therapeutic Class
Stimulant Laxative
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Chemical Structure
| Molecular Formula : | C18H15NNa2O9S2 |
| Chemical Structure : |  |
Common Questions about Sodium Picosulfate
What is Sodium Picosulfate?
Sodium Picosulfate belongs to the class of laxatives.
What are the uses of the Sodium Picosulfate?
Sodium Picosulfate is used in the treatment of constipation.
How long do I need to use Sodium Picosulfate before I see improvement in my condition?
Sodium Picosulfate is to be taken till the time you see an improvement in your health conditions.
At what frequency do I need to use Sodium Picosulfate?
Sodium Picosulfate should be taken in the dosage as prescribed by the doctor.
Should I use Sodium Picosulfate empty stomach, before food or after food?
Sodium Picosulfate should be taken at bed-time as it requires 6-8 hours to show effect.
What are the instructions for the storage and disposal of Sodium Picosulfate?
Sodium Picosulfate should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets.
Is Sodium Picosulfate safe for pregnant women?
Sodium Picosulfate is not prescribed to pregnant women unless necessary. Consult your doctor beforehand.
Is Sodium Picosulfate safe for breastfeeding women?
Breastfeeding women are not suggested to take Sodium Picosulfate unless necessary. Consult your doctor beforehand.
Is Sodium Picosulfate a habit forming drug?
No case of addiction has been reported yet.
What if I miss a dose of Sodium Picosulfate?
Take Sodium Picosulfate as soon as you remember. However, stick to your routine if it's the time for the next dose. Do not double the dose.
Quick Tips
- Together with Sodium Picosulfate, taking a fiber-rich diet containing whole grain bread and cereals, bran, fruits and green leafy vegetables, is essential to maintain healthy bowel function.
- Avoid taking a Sodium Picosulfate for more than 1 week, unless prescribed by the doctor, as it leads to dependency on the laxative action to produce a bowel movement.
- Take Sodium Picosulfate after 2 hours from other medicines, as it may interfere with the absorption of other medicines.
- Sodium Picosulfate should be preferably taken at bedtime because it requires 6 to 8 hours to show impact.
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