Andrographis paniculata

Available brands

Indications

Andrographis Paniculata capsule is indicated in-

Flu
Antiviral (Influenza, Hepatitis B, Herpes)
Common cold
Sinusitis
Upper respiratory tract infection (Sore throat, pharyngotonsillitis, bronchitis)
Stimulates the immune system
Antihepatotoxic
Hepato-biliary protective
Antipyretic
Antityphoid
Antifungal
Antihelminthic

Description

Andrographis paniculata is a herbaceous plant of acanthaceae family, native to India and Sri Lanka. Its common name is Kalomegh. It is widely cultivated in Southern Asia, where it is used to treat infections and some diseases, often being used before antibiotics were created. Mostly the leaves and roots were used for medicinal purposes.

Pharmacology

Andrographis compounds have shown antiviral properties which appear to inhibit glycoproteins in the virus. This impedes the ability of viruses to invade cells and replicate. It also has a major effect activating the general defense functions of the immune system by stimulating the production of antibodies as well as non-specific immune responses such as increased macrophage phagocytosis, rather than by any direct antimicrobial activity. Andrographis has flavonoids, which always have an anti-inflammatory effect. In vitro studies have shown that the flavonoid activities suppressed the genetic expression of neutrophils. Similarly, studies have indicated that a variety of inflammatory proteins, including COX-2, are reduced by the presence of Andrographoloid.

The aerial parts and their constituent andrographolides have antihepato-toxic activity in vitro and in vivo. In vitro studies have shown that intraperitoneal administration of a methanol extract of the aerial parts to mice reduced hepatotoxicity induced by carbon tetrachloride CCl4, and reversed CCl4 induced histopathological changes in the liver. Intraperitoneal administration of andrographolide to mice inhibited the CCl4 induced increase in the activity of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, bilirubin and hepatic triglycerides. Andrographolide, the major antihepatotoxic component of the plant, exerted a pronounced protective effect in rats against hepato-toxicity induced by CCl4, Dgalactosamine, paracetamol and ethanol.

Moreover, andrographolide and related diterpenes are choleretic, antidiarrheal, immunostimulant, antimalarial, antipyretic and active in urinary tract infections.

Dosage & Administration

Age 18 and above: 1 capsule 3 times daily after meal for 5 to 10 days.
12 to 17 years: 1 capsule 2 times daily after meal for 5 to 10 days.
4 to 11 years: 1 capsule daily after meal for 5 to 10 days or as directed by the physician.

* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন

Interaction

May have a synergistic effect with isoniazid.

Contraindications

Andrographis is contraindicated in cases of known allergy to plants of the acanthaceae family

Side Effects

Large oral doses may cause gastric discomfort, vomiting and loss of appetite. These side-effects appear to be due to the bitter taste of andrographolide.