Saccharomyces Boulardii

Available brands

Indications

Saccharomyces Boulardii is indicated for the prevention and treatment of following conditions:

Diarrhea associated with antibiotics
Traveler's diarrhea
Recurring intestinal disease caused by Clostridium difficile
Side effects of treatment for Helicobacter pylori
Symptoms of acute diarrhea
Diarrhea in infants
Crohn's disease
Ulcerative colitis and IBS

Composition

Each capsule contains-

Saccharomyces boulardii 250 mg (Eqv. to 5 billion CFU) or
Saccharomyces boulardii 500 mg (Eqv. to 10 billion CFU).

Pharmacology

Saccharomyces boulardii strain survives stomach acid to colonize in the intestinal tract while acting as a temporary flora to protect the beneficial organisms of the intestine. Additionally, it works with the body to re establish the microflora, thereby helping to maintain and support healthy immunity, digestion and gut health. It shows the following actions:

Anti-toxin activity: S. boulardii produces proteins that work to neutralize bacterial toxins. This may include the toxins produced by Clostridium diffcile.

Anti-microbial: S. boulardii adheres to pathogens, which decreases their adhesion to the intestinal wall and decreases invasion of enterocytes into the body. These pathogens are then removed during bowel movements.

Enzymatic activity: In healthy adults, S. boulardii increases the enzymatic activities (lactase, alpha glucosidase, alkaline phosphatase). The production of intestinal polyamines by S. boulardii is one of its most relevant and specific mechanisms of action. The polyamines spermidine, spermine, and putrescine enhance the expression of brush border enzymes (such as hydrolases, proteases, and transport molecules).

Immune Enhancement: S. boulardii helps prevent infection by stimulating the immune system along the GI lining by increasing the protective antibody IgA.

Anti-inflammatory: S. boulardii causes a decrease in pro-inflammatory cytokines.

Dosage & Administration

Adult:

For diarrhea associated with the use of antibiotics: 250-500 mg of Saccharomyces boulardii two to four times a day.
For diarrhea caused by Clostridium difficile: 1 gram of Saccharomyces boulardii daily for 4 weeks along with antibiotic treatment.
For reduction in symptoms of acute diarrhea: 250 mg of Saccharomyces boulardii twice a day for 5 days.
For diarrhea in Crohn's disease: 250 mg of Saccharomyces boulardii three times daily has been used for up to 9 weeks.
For diarrhea in ulcerative colitis: 250 mg of Saccharomyces boulardii three times daily.
For treatment of infections due to Helicobacter pylori: 250 mg-500 mg Saccharomyces boulardii twice daily in addition to usual treatment.
For diarrhea in Irritable bowel syndrome (IBS): 250 mg capsule twice daily.
For traveler's diarrhea: The recommended dosage is 250 mg capsule per day.

Children:

For reduction in symptoms of acute diarrhea: Children over three months are recommended to take two doses of 250 mg a day for five days. Children under three months are recommended to take 125 mg twice daily for five days.

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Interaction

Taking Saccharomyces boulardii with medications for fungal infections (e.g. fluconazole, itraconazole, terbinafine and others) can reduce the effectiveness of it.