Piperazine Citrate
Veterinary
Indications
Piperazine is used in infestations produced by nematode sensitive to piperazine, namely Ascaris, Oxyuris, some Strongyloides & Trichuris. The high doses are required to disinfect in case of poliparasitism makes this product the anthelmintic of selection due to its low toxicity. It is safely active against all adult forms as well as against some evolutive stages of worms where it is found to be a drug of first choice.
Highlighting Points:
Highlighting Points:
- Can be administered easily by mixing with dry food.
- as it is soluble in water so it can also be administered with liquid food
- Dose not hamper water and feed intake
- In recommended dose it has no side effects
Pharmacology
When exposed to Piperazine, worms suffer from hyperpolarization of their muscles which produces a reversible paralysis that prevents them from maintaining their position in the host’s gut, and they are voided with the feces.
Dosage & Administration
Cattle, Buffalo: 25-50 gm/100 kg body weight.
Horse: 25-30 gm/100 kg body weight.
Sheep, Goat: 4-8 gm/10 kg body weight.
Dog, Cat: 1-2.5 gm/10 kg body weight.
Poultry: 250 mg/kg or use according to the following dosage schedule:
10 gm powder in 6-8 litre of drinking Or 3.5 kg feed: 100 chicken (4-6 weeks) or 50-60 pullet or 20-30 layers
Horse: 25-30 gm/100 kg body weight.
Sheep, Goat: 4-8 gm/10 kg body weight.
Dog, Cat: 1-2.5 gm/10 kg body weight.
Poultry: 250 mg/kg or use according to the following dosage schedule:
10 gm powder in 6-8 litre of drinking Or 3.5 kg feed: 100 chicken (4-6 weeks) or 50-60 pullet or 20-30 layers
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Contraindications
The drug is contraindicated in poultry & animals with known hypersensitivity to active ingredients or renal failure.
Side Effects
Piperazine is very safe to use, the only occasional side effects are emesis and softening of the feces.
Pregnancy & Lactation
Piperazine may be administered to pregnant animals. However, risk/necessity should be considered during use in pregnant & lactating animals.
Precautions & Warnings
Food and drinking water should be stopped before 12 hours of administration of the drug.
Withdrawal Period-
Withdrawal Period-
- Poultry: Meat- 2 days, Egg- 2 days.
- Cattle: Meat- 1.5 days, Milk- 1 day.
Storage Conditions
Store in a cool & dry place, out of reach of children. Protect from light and moisture and keep away from food.
