Ivermectin (Topical)

Ivermectin causes hyperpolarization of the nerve or muscle cells of parasite, resulting paralyzed and death. For the protection of infestation caused by external parasites like ticks, mites, lice & fleas of livestock & poultry.

Ivermectin, a member of the avermectin class, causes death of parasites, primarily through binding selectively and with high affinity to glutamate-gated chloride channels, which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligandgated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The selective activity of compounds of this class is attributable to the fact that some mammals do not have glutamate-gated chloride channels, the avermectins have a low affinity for mammalian ligand-gated chloride channels, and Ivermectin does not readily cross the blood-brain barrier in humans.

For external use only.

Livestock: Pour on slowly from the withers to tail head at a dose of 1 ml (1 ml=50 drops)/10 kg body weight.

Poultry: Apply 5 drops/kg body weight topically & repeat the same dosage once after 14 days. Or, as directed by the registered Veterinary Physician.

May be administered to pregnant or lactating animal.

If the animal bath or expose to rain within 2 hours of treatment, efficacy of the drug may be reduced.

Withdrawal Period:

• Livestock: Meat- 15 days, Milk- Zero (0) day
• Poultry: Not known

Store in a cool and dry place, protected from light. Keep all medicines out of reach of children.