Diphenhydramine Hydrochloride

Veterinary

Indications

Diphenhydramine Hydrochloride is indicated for allergy of diverse origins such as-
  • Cutaneous allergies
  • Urticaria
  • Angioneurotic edema
  • Relief of coughing
  • Laminitis
  • Allergic reactions to medicaments
  • Anaphylactic shock
  • Insect bites
  • Eczema
  • Pruritis
  • Photosensitization

Pharmacology

Diphenhydramine Hydrochloride is an antihistaminic drug. It also has substantial sedative, anti-cholinergic, anti-tussive and anti-emetic effects. It inhibits histamine release by blocking H 1 receptors.

Dosage & Administration

Bolus: For oral administration only.
  • Large animals: 1 bolus/125-250 kg body weight.
  • Small animals: 1 mg/kg body weight.
  • Dogs, Cats: 2-4 mg/kg body weight 2-3 times daily.
Injection: For IV/IM use only.
  • Large animals: 1.25-2.50 ml/100 kg body weight (0.25 mg-0.50 mg/kg body weight)
  • Small animals: 1 ml/40 kg body weight (0.5 mg /kg body weight).
  • Dog: 0.25 ml/5 kg body weight (1 mg/kg body weight)
  • Cat: 0.1 ml/2 kg body weight (1 mg/kg body weight) Or, as Directed By Veterinary Physician.
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Contraindications

Animals hypersensitive to Diphenhydramine Hydrochloride or any other antihistamine.

Side Effects

CNS depression (drowsiness), anticholinergic (dry mouth, urinary retention), diarrhea etc. may occur in some cases.

Pregnancy & Lactation

Use in pregnancy has not been determined. However, risk & necessity should be considered during administration in pregnant & lactating animal.

Precautions & Warnings

Withdrawal Period: Meat-7 days, Milk-2 days.

Storage Conditions

Store in a cool and dry place, protected from light. Keep all medicines out of reach of children.