Levofloxacin Hemihydrate

Veterinary

Available brands

Indications

Levofloxacin oral solution is effective against both gram positive and gram negative bacteria, Mycoplasma and anaerobic organisms. Its wide spectrum of activity includes the pathogenic organisms like E. coli, Salmonella spp., Staphylococcus spp., Streptococcus spp., Klebsiella spp., Pseudomonas aeroginosa, Bordetella bronchiseptica, Mycoplasma spp., Clostridium perfringes and Camphylobacter. Diseases produced by these organism in poultry can effectively be treated with Levofloxacin oral solution.

Pharmacology

Levofloxacin is a synthetic, broad-spectrum, third generation fluoroquinolone derivative bactericidal antibiotic that actively killing bacteria by inhibiting bacterial DNA gyrase or the topoisomerase-IV enzyme, thereby inhibiting DNA replication and transcription. Levofloxacin used in prevention and treatment of Poultry CRD.

Dosage & Administration

Levofloxacin oral solution can be administered through drinking water at the following dosage rate-

For treatment: 1 ml per 1-2 litre of drinking water or 20 mg/kg bodyweight for 3-5 days.
For Prevention: 1 ml per 2-4 litre of drinking water or 10 mg/kg bodyweight for 3-5 days. Or as directed by the registered Veterinarian.

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Interaction

Magnesium & Aluminium containing substances may hamper the absorption of Levofloxacin from GI tract.

Contraindications

Levofloxacin is not recommended to use in combination with Chloramphenicol, Macrolides and Tetracyclines.

Side Effects

Levofloxacin is well tolerated for poultry at recommended dose. However, it may cause developmental cartilage abnormalities.

Precautions & Warnings

After the end of treatment, the watering system should be cleaned appropriately to prevent drug resistance. It should not be used for poultry resistant to any Quinolone derivative because cross resistance may develop. In case of broilers the drug should be withdrawn four Days prior to slaughter & for layer should be withdrawn within seven days prior to laying period.

Withdrawal Period: Meat- Four days, Egg- Seven days.