Tafluprost + Timolol

This ophthalmic solution is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

This is a combination of prostaglandin analog-Tafluprost and & beta-adrenergic receptor inhibitor, Timolol Maleate. Tafluprost is prostaglandin analog which is a selective FP prostanoid receptor agonist is believed to reduce intraocular pressure by increasing uveoscleral outflow of aqueous humor. Timolol is a non-selective β-adrenergic receptor blocker. Exact mechanism of ocular hypotensive effect is unclear, but it is thought to be related to reduction of aqueous humor formation.

Instill one drop in the affected eye once daily in the evening.

No interaction studies have been performed.

Hypersensitivity to the active substances or to any of the excipients.

The most frequently reported treatment-related adverse reaction is ocular hyperemia. Rare side effects observed include eye irritation and blurred vision.

Pregnancy: Pregnancy Category C. There are no adequate and well-controlled studies in pregnant woman. The product should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.

Nursing Mothers: It is not known whether the drug or its metabolites are excreted in human milk. Caution should be exercised when product is administered to a nursing woman.

Pigmentation: Tafluprost ophthalmic solution has been reported to cause changes to pigmented tissues. The most frequently reported changes have been increased pigmentation of the iris, periorbital tissue (eyelid) and eyelashes.

Eyelash Changes: The Product may gradually change eyelashes and vellus hair in the treated eye. These changes include increased length, color, thickness, shape and number of lashes. Intraocular Inflammation: should be used with caution in patients with active intraocular inflammation (e.g., iritis/uveitis).

Macular Edema: Macular edema & cystoid macular edema has been reported during treatment with prostaglandin F2α analogs.

Pediatric Use: Use in pediatric patients is not recommended because of potential safety concerns related to increased pigmentation following long-term chronic use.

Geriatric Use: No overall clinical differences in safety or effectiveness have been observed between elderly and other adult patients.

Drugs for miotics and glaucoma

Store in a cool & dry place, protect from light. Keep out of the reach of children.

preservative containing sterile eye drops: It is desirable that the contents should not be used more than 30 days after first opening.

Preservative free sterile eye drops: Store unopened container at 2°C to 8°C (in a refrigerator). After opening, Do not store above 25°C. Store in dry place protected from light. Keep out of reach of children. Do not touch the dropper tip to any surface. It is desirable that the contents should not be used more than 60 days after first opening of the bottle. Protect from freezing.