Coenzyme Q10 [Ubidecarenone]
Indications
Coenzyme Q10 is indicated in
Infertility-
Infertility-
- Female infertility (e.g, Poor ovarian reserve and Polycystic ovary syndrome)
- Male infertility
- Myopathy
- Ataxia
- Genetic Neuromuscular Disease
- Migraine
- Muscular Dystrophy
- Parkinson's Disease
- Alzheimer's Disease
- Congestive Heart Failure (CHF)
- Hypertension
- Angina
- Cardiomyopathy
- Heart Protection During Surge
- Periodontal Gum Disease
- Diabetes
- Exercise Performance
- Cancer
- Asthma
- Thyroid Disorder
Pharmacology
The USP refers to Coenzyme Q10 as Ubidecarenone which is a fat-soluble vitamin like substance. It is presented in every cell of the body and acts as a vital intermediate of the electron transport system in the mitochondrial membrane for cellular respiration and ATP production. The highest requirement of Ubidecarenone is found in the cells and tissues that are of metabolically active such as- heart, immune system, skeleton muscle, gingiva and most susceptible to Ubidecarenone deficiency. The Production of Ubidecarenone slows down with advancing age and thus contribute in manifestation of aging.
As Ubidecarenone is a lipophilic substance, it is absorbed less on an empty stomach and absorbed in greater amount when taken with food of high lipid content. Thus, after oral administration, Ubidecarenone is absorbed from the small intestine into the lymphatics system and then taken up by the liver where it is incorporated into lipoproteins and released into the blood circulation and at that time concentrated in the tissues.
Ubidecarenone is distributed to the various tissues of the body and is able to enter into the brain. The concentration varies from tissue to tissue and those with high rates of metabolic activity and high energy demands such as heart, muscle, liver, kidney and brain contain relatively high concentration of Ubidecarenone. Ubidecarenone is metabolized in all tissues in the body. Approximately 60% of an oral dose of Ubidecarenone is excreted in the feces. The main elimination of Ubidecarenone occurs with bile.
As Ubidecarenone is a lipophilic substance, it is absorbed less on an empty stomach and absorbed in greater amount when taken with food of high lipid content. Thus, after oral administration, Ubidecarenone is absorbed from the small intestine into the lymphatics system and then taken up by the liver where it is incorporated into lipoproteins and released into the blood circulation and at that time concentrated in the tissues.
Ubidecarenone is distributed to the various tissues of the body and is able to enter into the brain. The concentration varies from tissue to tissue and those with high rates of metabolic activity and high energy demands such as heart, muscle, liver, kidney and brain contain relatively high concentration of Ubidecarenone. Ubidecarenone is metabolized in all tissues in the body. Approximately 60% of an oral dose of Ubidecarenone is excreted in the feces. The main elimination of Ubidecarenone occurs with bile.
Dosage & Administration
For Co-enzyme Q10 deficiency: 150 mg daily.
For mitochondrial disorders: 150-160 mg, or 2 mg/kg/day.
For heart failure in adults: 100 mg per day divided into 2 or 3 doses.
For recent myocardial infarction: 120 mg daily in 2 divided doses.
For high blood pressure: 120-200 mg per day divided into 2 doses.
For isolated systolic hypertension: 60 mg twice daily.
For preventing migraine headache: 100 mg three times daily.
For Parkinson's disease: 300 mg, 600 mg, 1200 mg and 2400 mg per day in 3-4 divided doses.
For infertility in men: 200-300 mg per day.
For muscular dystrophy: 100 mg per day.
Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help to reduce side effects.
For mitochondrial disorders: 150-160 mg, or 2 mg/kg/day.
For heart failure in adults: 100 mg per day divided into 2 or 3 doses.
For recent myocardial infarction: 120 mg daily in 2 divided doses.
For high blood pressure: 120-200 mg per day divided into 2 doses.
For isolated systolic hypertension: 60 mg twice daily.
For preventing migraine headache: 100 mg three times daily.
For Parkinson's disease: 300 mg, 600 mg, 1200 mg and 2400 mg per day in 3-4 divided doses.
For infertility in men: 200-300 mg per day.
For muscular dystrophy: 100 mg per day.
Dividing the total daily dose by taking smaller amounts two or three times a day instead of a large amount all at once can help to reduce side effects.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Interaction
Statins: The statin drugs reduce endogenous synthesis of Ubidecarenone in the body. Thus, Ubidecarenone supplement may increase Ubidecarenone levels without adversely affecting statin drug's efficacy.
Warfarin: May reduce the effectiveness of warfarin.
Beta-blockers: Beta blockers (particularly propanolol) have been reported to inhibit some Ubidecarenone dependent enzymes,
Antidiabetic medications: May improve glycemic control in some type II diabetics. If this occurred, antidiabetic medications may need appropriate dose adjustment.
Doxorubicin: May help ameliorate the cardiotoxicity of doxorubicin।
Warfarin: May reduce the effectiveness of warfarin.
Beta-blockers: Beta blockers (particularly propanolol) have been reported to inhibit some Ubidecarenone dependent enzymes,
Antidiabetic medications: May improve glycemic control in some type II diabetics. If this occurred, antidiabetic medications may need appropriate dose adjustment.
Doxorubicin: May help ameliorate the cardiotoxicity of doxorubicin।
Contraindications
Co-enzyme Q10 is contraindicated in patients who have hypersensitivity to the active substance or to any of the excipients. It is also contraindicated in patients scheduled for surgery in the next two weeks.
Side Effects
Co-enzyme Q10 is safe for most adults. It can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people.
Pregnancy & Lactation
Co-enzyme Q10 should not be used in pregnancy and breast-feeding.
Precautions & Warnings
Co-enzyme Q10 may lower blood sugar levels, so caution should be taken in patients with diabetes or hypoglycemia. Co-enzyme Q10 may decrease blood pressure so caution is advised in patients with low blood pressure or taking blood pressure medications.
Therapeutic Class
Herbal and Nutraceuticals, Supplements & adjuvant therapy
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
