Oxytetracycline

Veterinary

Available brands

Indications

Oxytetracycline bolus tablet:

Cattle, Bultalo, Sheep and Goat: Anthrax, haemorrhagic septicaemia, black quarter, rinderpest, brucellosis, pyebnephritis, calf scour, infectious enteritis, malignant edema, dysentery, pneumonia, navel ill, liver infection, abscess, mastitis, pyometra, metritis, peritonitis, kiptospirosis, infectious plauropneumonia, calf diphtheria, castration, paratyphoid, foot-rot, salmonellosis, actinomycosis, anaplasmosis and secondary infections in FMD.
Dog, Cat: Pneumonia, pleurisy, bronchitis, infectious enteritis and secondary infections in distemper.

Oxytetracycline powder is an antibiotic for poultry, cattle, goat, shrimps, fresh water fishes & aquarium fishes used in feed or drinking water for prevention and treatment of bacterial diseases. Poultry diseases have been a major target of Oxytetracycline medication.

Poultry: Colibacillosis (E. coli), infectious coryza (Haemophilus gallinarum), mycoplasmosis, chronic respiratory diseases, airsacculitis, infectious synovitis (Mycoplasma gallisepticum, Mycoplasma meleagridis, Mycoplasma synoviae) clostridial dermatitis (Clostridium septicum), necrotic enteritis (Clostridium perfringens, types A & C), pullorum disease (Salmonella pullorum) fowl cholera, coccidiosis etc.
Cattle, Buffalo, Sheep and Goat: Anthrax, haemorrhagic septicaemia, black quarter, rinderpest, brucellosis, calf scour, infectious enteritis, dysentery, pneumonia, navel ill, liver infection, abscess, mastitis, pyometra, metritis, peritonitis, infectious pleuropneumonia, calf diphtheria, paratyphoid, foot-rot, salmonellosis, actinomycosis, anaplasmosis and secondary infections in viral diseases.

Long-acting injectable solution: For the treatment and prevention of different types of bacterial diseases of cattle, buffalo, sheep, goat, deer, rabbit and poultry.

Cattle, Buffaloes, Sheep, Goat & Deer: For the treatment of actinobacillosis, bacterial enteritis, bacterial pneumonia, bovine respiratory disease complex, diphtheria, keratoconjunctivitis (pink eye), leptospirosis, metritis, anaplasmosis, foot-rot, black leg, navel ill, joint ill, heart water, dermatophilosis, enzootic abortion (bedsoniasis), wound infections, mycoplasmosis, Aid in the control or prevention of shipping fever, pneumonia, post operative and post parturient infections.
Rabbit: For the prevention and treatment of conditions / diseases susceptible to Oxytetracycline including infections due to Pasteurella multocida, Bordetella brochoseptica, Escherichia coli and Salmonella spp etc.
Poultry: For the prevention and treatment of conditions / diseases susceptible to Oxytetracycline including fowl cholera, fowl typhoid, complicated CRD etc.

Pharmacology

Oxytetracycline is under group of Tetracycline’s which bind to the 30s ribosomal subunit of bacterial ribosome and interfere with the binding of aminoacyl-tRNA to the mRNA molecule in ribosome complex. Thereby interfere with bacterial protein synthesis in growing or multiplying bacteria leading to bacteriostatic but higher concentration results bacteriocidal action.

Dosage & Administration

Oxytetracycline bolus tablet:
Cattle and Buffalo 50-100 kg-

Preventive: ½ caplet
Curative: 1 caplet
Disease of the respiratory tract and others: 2-4 caplets

Sheep and Goat 10-20 kg

Preventive: ½-2/3 caplet
Curative: 1 caplet
Disease of the respiratory tract and others: 1 caplet

Horse Up to 150 kg

Preventive: 1 caplet
Curative: 1-1½ caplet
Disease of the respiratory tract and others: 2 caplets

Horse Above 150 kg

Preventive: 1½-2 caplets
Curative: 2-3 caplet
Disease of the respiratory tract and others: 3-4 caplets

Dog and Cat

Disease of the respiratory tract and others:½ caplet

Oxytetracycline powder:
Treatment: Oxytetracycline powder as 100 mg/kg body weight or 1 gm per 2.5 litre drinking water for 3-5 consecutive days or 50 gm per 100 kg feed for 7 consecutive days.

Prevention/Growth Promotion: Oxytetracycline powder as 50 mg/kg body weight or 1 gm per 5 litre drinking water for 3-5 consecutive days or 35 gm per 100 kg feed for 7-10 consecutive days.

Calves:

Treatment: 40 mg Oxytetracycline per kg body weight for 3-5 consecutive days.
Prevention/ Growth Promotion: 20 mg Oxytetracycline powder per kg body weight for 7-10 consecutive days.

Fishes: 11 gm-16 gm Oxytetracycline powder per 100 kg fishes.
Honey Bees: 0.5 gm Oxytetracycline powder per colony. Usually 3 dustings are required at 4-5 days interval.

Long-Acting Injectable Solution:

Cattle, Buffaloes, Sheep, Goat & Deer: Single dose treatment of 1 ml per 10 kg body weight. (or, 20 mg per kg body weight) by IM route.
Poultry & Rabbit: Single dose treatment of 0.25 ml per kg body weight (or, 50 mg per kg body weight) by subcutaneous route. Severe infections may require re-treatment at 3 to 5 days following initial injection. Or, as advised by the veterinary physician

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Interaction

With medicine: Efficacy of penicillin, iron dextran can be decreased when used with Oxytetracycline. The serum concentration of Oxytetracycline can be decreased when used with Bismuth subsalicylate, Calcium gluconate/lactate, aluminium, magnesium & zinc salts. Allow 2-3 hours between doses of oxytetracycline and antacids.

With feed & others: Not known.

Contraindications

Oxytetracycline Powder is contraindicated to use with calcium containing drug or food.

Side Effects

General toxicity is low although collapse has been reported with tetracycline in weak and debilitated animals.

Pregnancy & Lactation

Oxytetracycline Powder should not be used during pregnancy because of the risk of hepatotoxicity in the mother as well as the effects on the developing fetus. Use in pregnancy and lactation may result in impaired bone growth and reduce milk production.

Precautions & Warnings

Milk from lactating cows should not be taken for human consumption during treatment for 48 hours thereafter. Oxytetracycline powder should not be administered to fish for more than 12 consecutive days without at least a
few days break.